Research
Department for Theoretical Biology at the University of Bonn

Publications | Cellular movement | Swarms and search strategies | Biological surfaces and biofilms | Evolutionary ecology and dynamics | Collective knowledge in biological systems | Diese Seite auf Deutsch

Research articles in peer-reviewed journals

Bock M, Tyagi AK, Kreft JU and Alt W (2010) Generalized Voronoi Tessellation as a Model of Two-dimensional Cell Tissue Dynamics. Bulletin of Mathematical Biology 72(7)1696-1731.

Alt W and Kuusela E (2009) Continuum model of cell adhesion and migration. Journal of Mathematical Biology 58(1-2):135

Alt HW and Alt W (2009) Phase boundary dynamics: transition between ordered and disordered lipid monolayers. Interfaces and Free Boundaries 11(1):1-36

Reiter P, Felix D, von der Mosel H, Alt W (2009) Energetics and dynamics of global integrals modeling interaction between stiff filaments. Journal of Mathematical Biology 59(3):377-414

Albeverio S and Alt W (2008) Stochastic dynamics of viscoelastic skeins: condensation waves and continuum limits. Mathematical Models and Methods in Applied Sciences 18(1):1149-1191

Csikasz-Nagy A, Gyorffy B, Alt W, Tyson JJ, Novak B (2008) Spatial controls for growth zone formation during the fission of yeast cell cycle. Yeast 25(1):59-69

Hecker D, Kappler J, Glassmann A, Schilling K, Alt W (2008) Image analysis of time-lapse movies - A precision control guided approach to correct motion artefacts. Journal of Neuroscience Methods 171(1):67-73

Dötsch A, Severin J, Alt W, Galinski EA, Kreft JU (2008) A mathematical model for growth and osmoregulation in halophilic bacteria. Microbiology 154(10):2956-2969

Picioreanu C, Kreft JU, Klausen M, Haagensen JAJ, Tolker-Nielsen T, Molin S (2007). Microbial motility involvement in biofilm structure formation - a 3D modelling study. Water Science and Technology 55:337-343

Merkle T, Rost M, Alt W (2006) Egocentric path integration models and their application to desert arthropods. Journal of Theoretical Biology 240(3):385-399

Costa E, Pérez J, Kreft JU (2006) Why is metabolic labour divided in nitrification? Trends in Microbiology 14:213-219

Klausen M, Gjermansen M, Kreft JU, Tolker-Nielsen T (2006) Dynamics of development and dispersal in sessile microbial communities: examples from Pseudomonas aeruginosa and Pseudomonas putida model biofilms. FEMS Microbiology Letters 261:1-11

Dai L, Alt W, Schilling K, Retzlik J, Gieselmann V, Magin T M, Kappler J (2005) A fast and robust quantitative time-lapse assay for cell migration. Experimental Cell Research 311(2):272-280

Grijspeerdt K, Kreft JU, Messens W (2005) Individual-based modelling of growth and migration of Salmonella enteritidis in hen's eggs. International Journal of Food Microbiology 100:323-333

Peltomäki M, Vuorinen V, Alava M, Rost M (2005) Host-parasite models on graphs. Physical Review Letters 72:046134

Picioreanu C, Kreft JU, van Loosdrecht MCM (2004) Particle-based multidimensional multispecies Biofilm model. Applied and Environmental Microbiology 70:3024

Vuorinen V, Peltomäki M, Rost M, Alava MJ (2004) Networks in metapopulation dynamics. European Physical Journal B 38:261

Kreft JU (2004) Biofilms promote altruism. Microbiology 150:2751

Kreft JU (2004) Conflicts of interest in biofilms. Biofilms 1:265

van Loosdrecht MCM, Heijnen JJ, Eberl H, Kreft JU, Picioreanu (2002) Mathematical modelling of biofilm structures. Antonie van Leeuvenhook 81:245

Libotte T, Kaiser H-W, Alt W and Bretschneider T (2001) Polarity, protrusion-retraction dynamics and their interplay during keratinocyte cell migration. Experimental Cell Resarch 270:129

Alt W and Dembo M (1999) Cytoplasm dynamics and cell motion: two-phase flow models. Mathematical Biosciences 156:207

Deutsch A, Lawniczak AT (1999) Probabilistic lattice models of collective motion and aggregation: from individual to collective dynamics. Mathematical Biosciences 156:255

Hinz B, Alt W, Johnen Ch, Herzog V and Kaiser HW (1999) Quantifying lamella dynamics of cultured cells by SACED, a new computer-assisted motion analysis. Experimental Cell Resarch 251:234

Heijnowicz Z, Sondag, C, Alt W and Sievers A (1998) Graviperception in intermittently stimulated cress roots. Temporal course and thresholds. Plant, Cell and Environment 21:1293-1300

Bussemaker HJ, Deutsch A, Geigant E (1997) Mean-field analysis of a dynamical phase transition in a cellular automaton model for collective motion. Physical Review Letters 78:5018

Deutsch A (1996) Orientation-induced pattern formation: swarm dynamics in a lattice-gas automaton model. International Journal of Bifurcation and Chaos 6:1735

Tranquillo RT and Alt W (1996) Stochastic model of receptor-mediated cytomechanics and dynamic morphology of leukocytes. Journal of Mathematical Biology 34:361-412

Alt W (1996) Biomechanics of actomyosin related motility in keratinocytes. Biofizika 41:181-188

Alt W (1995) Elements of a systematic search in animal behavior and model simulations. Biosystems 34:11-26 (Special volume "Biological and Evolutionary Information Systems")

Alt W, Brosteanu O, Hinz B and Kaiser HW (1995) Patterns of spontaneous motility in videomicrographs of human epidermal keratinocytes. Biochemistry and Cell Biology 73:441-459

Alt W (1995) Elements of systematic search in animal behaviour and model simulations. Biosystems 34:11

Alt W and Tranquillo RT (1995) Basic morphogenetic system modeling shape changes of migrating cells: How to explain fluctuating lamellipodial dynamics. Journal of Biological Systems 3:905-916

Othmer HG, Dunbar SR and Alt W (1988) Models of dispersal in biological systems. Journal of Mathematical Biology 26(3):263

Alt W, Lauffenburger D A (1987) Transient behavior of a chemotaxis system modelling certain types of tissue inflammation. Journal of Mathematical Biology 24(6):691-722

Greenberg JM and Alt W (1987) Stability results for a diffusion equation with functional drift approximating a chemotaxis model. Transactions of the American Mathematical Society 300(1):235

Alt W, Tyson J J (1987) A stochastic model of cell division (with application to fission yeast). Mathematical Biosciences 84(2):159-187

Book articles

Alt W, Bock M, and Möhl Ch (2010) Coupling of cytoplasm and adhesion dynamics determines cell polarization and locomotion. In: (A. Chauviere, L. Preziosi, and C. Verdier, eds.) Cell Mechanics: From Single-Scale Based Models to Multiscale Modelling. Chapman & Hall / CRC, pp. 86-125

Alt W, Bretschneider T, and Müller R (2003) Interactive movement, aggregation and swarm dynamics. In: (W. Alt, M. Chaplain, M. Griebel, J. Lenz, editors) Polymer and Cell Dynamics. Multiscale Modelling and Numerical Simulation. Birkhäuser, Basel, pp. 221-242

Alt W (2002) Nonlinear hyperbolic systems of generalized Navier-Stokes type for interactive motion in biology. In: (S. Hildebrandt, H. Karcher, editors) Geometric Analysis and Nonlinear Partial Differential Equations. Springer, Berlin, pp. 431-461

Alt W (1999) Statistics and dynamics of cellular shape changes. In: (M.A.J. Chaplain, G.D. Singh, J.C. McLachlan, editors) On Growth and Form. Spatio-Temporal Pattern Formation in Biology. Wiley, Chichester, pp. 287-307

Mogilner A, Deutsch A, Cook J (1997) Models for spatio-angular self-organization in cell biology. In: (W. Alt, G. Dunn, A. Deutsch, editors) Dynamics of cell and tissue motion. Birkhäuser, Basel, pp. 173-182

Alt W, Tranquillo RT (1997) Protrusion-retraction dynamics of an annular lamellipodal seam. In: (W. Alt, G. Dunn, A. Deutsch, editors) Dynamics of Cell and Tissue Motion. Birkhäuser, Basel, pp. 73-81

Teplov VA, Romanovsky YuM, Pavlov DA and Alt W (1997) Auto-oscillatory processes and feedback mechanisms in physarum plasmodium motility. In: (W. Alt, G. Dunn, A. Deutsch, editors) Dynamics of cell and tissue motion. Birkhäuser, Basel, pp. 83-92

Alt W and Tranquillo RT (1995) Basic morphogenetic system modeling shape changes of migrating cells: how to explain fluctuating lamellipodial dynamics. In: Proceedings of the 2nd European conference in mathematics applied in biology and medicine, Lyon 1993. World Scientific, Toronto. J. Biological Systems 3(4):905-916

Tranquillo RT, Brosteanu O, Alt W (1994) Dynamic morphology of leukocytes: Statistical analysis and a stochastic model for receptor-mediated cell motion and orientation. In: (N. Akkas, editor) Biomechanics of Active Movement and Division of Cells. Nato ASI Series H 84. Springer, Berlin, pp. 437-443

Alt W, Kaiser HW (1994) Observation, modeling and simulation of keratinocyte movement. In: (N. Akkas, editor) Biomechanics of Active Movement and Division of Cells. Nato ASI Series H 84. Springer, Berlin, pp. 445-451

Alt W (1994) Cell Motion and Orientation. Theories of elementary behavior between environmental stimulation and autopoietic regulation. In: (S.A. Levin ed.) Frontiers in Mathematical Biology. Lecture Notes in Biomathematics, Vol. 100. Springer, Berlin, pp. 79-101

Alt W (1990) Mathematical models and analysing methods for the lamellipodial activity of leukocytes. In: (N. Akkas, editor) Biomechanics of Active Movement and Deformation of Cells. Nato ASI Ser. H 42. Springer, pp. 403-422

Alt W (1987) Mathematical models in actin-myosin interaction. In: (K.E. Wohlfarth-Bottermann, editor) Nature and Funktion of Cytoskeletal Proteins in Motility and Transport. Fortschritte der Zoologie 34, pp. 219-230

Comments, opinion articles, and reviews

Bock M, Wollnik C (2011) How do biological cells move? European Communications in Mathematical and Theoretical Biology 14:54

Alt W (2010) Model-supported data analysis: some biological principles and examples. Journal of Mathematical Biology 61(6):899-903

Hense BA, Kuttler C, Müller J, Rothballer M, Hartmann A, Kreft JU (2007) Does efficiency sensing unify quorum and diffusion sensing? Nature Reviews Microbiology 5:230-239

Kreft JU, Bonhoeffer S (2005) The evolution of groups of cooperating bacteria and the growth rate versus yield trade-off. Microbiology 151:637

Books and special issues

Bock M, Knappitsch MP, editors (2011) European Communications in Mathematical and Theoretical Biology 14. Special issue at the 25th anniversary of Wolfgang Alt's Theoretical Biology group at the University of Bonn

Alt W, Eibach U, Herzog V, Schleim S, Schütz G (2010) Lebensentstehung und künstliches Leben - Naturwissenschaftliche, philosophische und theologische Aspekte der Zellevolution. Die graue Edition, Zug/Schweiz. 405 pp.

Alt W, Chaplain M, Griebel M, Lenz J (2003) Polymer and cell dynamics - multiscale modelling and numerical simulations. Birkhäuser, Basel. 290 pp.

Alt W, Deutsch A, Dunn G, editors (1997) Dynamics of cell and tissue motion. Birkhäuser, Basel. 336 pp.

Alt W and Hoffmann G, editors (1990): Biological Motion. Proceedings of a Workshop, Königs­winter 1989. Lecture Notes in Biomathathematics, Vol. 89, Springer, Berlin. 511 pp.

History of biology

Alt W (2010) Entwicklung der Theoretischen Biologie und ihre Auswirkung auf die Disziplingenese im 20. Jahrhundert. Verhandlungen zur Geschichte und Theorie der Biologie 15:103-135

Alt W (2005) Campus Poppelsdorf 1859-1884: 25 Jahre Entwicklung einer interfakultären Forschungsstätte für Physiologie und Zellbiologie. Verhandlungen zur Geschichte und Theorie der Biologie 11:187-201

Alt W (2002) Roots of theoretical biology: 100 years ago. European Communications in Mathematical and Theoretical Biology 3:16-20

Alt W, Deutsch A, Kamphuis A, Lenz J and Pfistner B (1996) Zur Entwicklung der theoretischen Biologie: Aspekte der Modellbildung und Mathematisierung. Jahrbuch zur Geschichte und Theorie der Biologie 3:7-59